Navigating the world of hair loss treatment is hard work. Minoxidil, 5AR blockers, DHT blockers, it’s possible you’ve tried or at the very least, looked into them all. You want your hair to start growing back, but you’re also worried about the risk of side effects. It can be so hard to decide on the right treatment when you’re seeking a solution that is effective and safe. We’re here to give you the information you need.
Could Fluridil or Eucapil be a promising option for you? How does it compare to the other treatments on the market?
In this comprehensive guide, we’ll explore Fluridil for hair loss, how it works, its safety profile and potential side effects. We will even go through the most frequently asked questions to help you make an informed decision. With this knowledge, you can decide if Fluridil is the right choice for your hair regrowth journey, bringing you one step closer to addressing your concerns.
What is Fluridil?
Fluridil, also known as Eucapil or topilutamide is a topical antiandrogen specifically designed to treat hair loss caused by androgenetic alopecia, a common form of hair loss affecting both men and women. Fluridil is different to other popular hair loss treatments such as minoxidil and finasteride. Instead, fluridil is a non-steroidal anti-androgen (NSAA for short). It works by stopping dihydrotestosterone (DHT) binding to androgen receptors on hair follicles.1 It shares this mechanism of action with other hair loss treatments such as RU-58841 and pyrilutamide. By doing so, it slows down hair loss and can even stimulate new hair growth, offering a potential solution for those struggling with thinning hair or balding.
How Does Fluridil/Eucapil for hair loss work?
The primary driving force behind male and female pattern hair loss is DHT, a hormone derived from testosterone. DHT binds to androgen receptors on hair follicles, causing the activation of genes which starts a process called follicular miniaturization.1 This causes hair follicles to shrink and weaken over time, eventually leading to thinning, breaking and hair loss. Fluridil prevents DHT from binding to these receptors and so reduces the risk of miniaturization and damage from DHT.
Does fluridil for hair loss work? What does the research say?
There is research to suggest that topical use of fluridil for hair loss is effective in both female and male patients while not being absorbed into the bloodstream or causing side effects. Here we take a look at some of the studies into fluridil for hair loss and the evidence behind it
Minimal systemic absorption and inactive metabolites
Fluridil is metabolized in the human body into a compound called BP-34. BP 34 was tested on a line of human cells with androgen receptors and found to have no anti-androgen activity. The androgen receptor activity of fluridil was found to be 97%. (link)
What this means is that when applied to the scalp, fluridil could be expected to have good local action on androgen receptors in the scalp, after which it is quickly broken down into an inactive form which minimises the risk for side effects from androgen receptor blocking elsewhere in the body. This was backed up by a placebo-controlled study of topical fluridil in which sexual function, libido and blood markers were found to be normal after 90 days of daily use.2
Studies on Eucapil for hair loss in female patients
In a 9-month open study, the effect of hair growth on Eucapil (which contains 2% fluridil in isopropanol alcohol), was tested on 11 women with an average age of 35 years suffering from androgenetic alopecia (AGA). While no significant changes in the anagen/telogen percentage ratio were observed after 6 and 9 months but the study found that Eucapil stopped the progression of AGA after 9 months of treatment. The study also found that the diameter of hair stems in the growth phase had increased significantly after 6 and 9 months. Two participants discontinued the study due to skin irritation, which was attributed to the isopropanol component of Eucapil. Importantly, no changes in blood tests or biochemical values were detected, and self-reported questionnaires from the study participants suggested that there were no systemic side effects.3
Studies on fluridil for hair loss in male patients
In a double-blind, placebo-controlled study of 43 men with AGA, 2% Fluridil was used for 3 months, and its effects were evaluated using photographic tests, blood tests, and blood chemistry. The study continued for 9 months.
The average percentage of hairs in the growth phase remained unchanged in the placebo group, but increased from 76% to 85% in the fluridil group and further to 87% after 9 months.
The placebo group were subsequently placed on fluridil and their percentage of hairs in the growth phase increased from 76% to 85% after 6 months. Sexual functions, libido, blood tests, and blood chemistry remained normal and no detectable Fluridil or BP-34 was found in the serum.2
Fluridil for hair loss – how long until I see results?
Stopping hair loss and achieving regrowth is a gradual process and results from medications such as fluridil usually take time to become clear. Generally, users report a decrease in hair loss within 4-6 weeks, with more significant improvements in hair growth and thickness taking several months. In the human studies of fluridil for hair loss, researchers found that the “maximum attainable effect of fluridil was achieved within the first 90 days of use.” 2
Stability and storage of Fluridil for hair loss
One of Fluridil’s notable features is very unstable in presence of any water. That is why the product is formulated without any water and packaged in sealed ampoule to avoid any water getting into the product. Eucapil is metabolized readily in the human body. Studies in which 2% fluridil was applied to the scalp could not detect fluridil or its decomposition product, BP-34, in the blood at 0, 3, or 90 days.2
The quick degradation of fluridil can be an advantage. When absorbed into the watery environment of the bloodstream, Fluridil quickly degrades into inactive metabolites, which helps to minimize any potential systemic side effects. This rapid degradation ensures that the treatment remains localized to the scalp, where it’s most needed.
To maintain Fluridil’s effectiveness, it’s essential to store it properly. Keep the product at room temperature and protect it from direct sunlight and moisture. Fluridil’s shelf life is typically around 2-3 years although one study concluded that it is stable for 5 years when stored at 20oc or 68oF. It is important to stick to recommended storage conditions and the expiration date printed on the packaging. Using expired or improperly stored Fluridil may result in reduced effectiveness or potential irritation.2,4
How to Use Fluridil/Eucapil for hair loss
Using Fluridil correctly is key to achieving optimal results. Before application, ensure your scalp and hair are clean and dry. Apply a 2 ml ampoule of Fluridil solution to the affected areas of your scalp, gently massaging it in to promote absorption. Avoid applying Fluridil to broken skin, and be careful not to let the solution come into contact with your eyes.
Step-by-step instructions for using fluridil for hair loss
For optimal efficiency:
- The recommended dose is one ampule (2 ml) per day, applied to the scalp at bedtime.
- Apply Eucapil/Fluridil directly to the affected scalp region.
- Do not use Eucapil on a wet scalp or damp hair because fluridil degrades very quickly in a water environment.
- Avoid coming into contact with water after using fluridil
- Wash hair as late as possible after application to allow fluridil the best chance of working.
- Carefully break off the top of the Eucapil ampule.
- Put the tip of the applicator on the open ampule. Apply in front of a mirror.
- Apply fluridil directly to the scalp with the head inclined back to promote dispersion and prevent eye contact
- With the ampule inverted, apply fluridil in a circular motion while squeezing the applicator repeatedly.
- Massage your scalp gently.
Consistency is key
Once you find the right hair loss treatment, consistent and continuous long-term use is necessary to maintain any results and fluridil is no different. For best results, apply fluridil once daily, ideally in the evening. Consistency is crucial, so make sure to use the treatment every day for the duration recommended by your healthcare provider. Skipping applications or using fluridil sporadically may limit its effectiveness. Stopping fluridil will mean DHT will cause
Potential Side Effects and Precautions
Despite its favorable safety profile, Fluridil can still cause some side effects. The most common side effects include scalp irritation, redness, dryness, and itching and are associated with the isopropyl alcohol in which fluridil is dissolved. These symptoms are generally mild and tend to resolve on their own with continued use. However, if side effects persist or worsen, it’s essential to consult a healthcare professional. Patients with a propensity toward seborrheic dermatitis (scalp irritation) may experience a flare-up of their condition attributable to isopropyl alcohol.
Rarely, Fluridil can cause allergic reactions in some individuals. If you experience symptoms like rash, hives, or difficulty breathing, discontinue use immediately and seek medical attention.
Grape seed oil is another inactive ingredient in Eucapil, there are no known side effects associated with grape seed oil, however people who are allergic to grapes should not use it as it can cause allergic reactions.
Before starting Fluridil it’s essential to consult with a healthcare professional to ensure it’s the right treatment for your specific hair loss concerns. Always follow their recommendations and use the product as directed. Avoid contact with your eyes and broken skin, as this can cause irritation or other complications.
Differences Between Fluridil and Other Hair Loss Treatments
How does fluridil stack up to other treatments such as finasteride, dutasteride, RU58841, and pyrilutamide and why might it be a better option for you?
Fluridil vs. Finasteride and Dutasteride
Finasteride and dutasteride are oral medications known as 5-alpha-reductase inhibitors. They block the conversion of testosterone to dihydrotestosterone (DHT). While these medications have been proven effective, some individuals experience side effects like decreased libido, erectile dysfunction and delayed ejaculation.
Fluridil, on the other hand, is a topical treatment that targets androgen receptors in the hair follicles without being absorbed into the bloodstream. This means it has minimal systemic side effects and could be a preferable option for some people.
Fluridil vs. RU58841 and Pyrilutamide
RU58841 and pyrilutamide are also topical antiandrogens like Fluridil. They work by blocking the androgen receptors in hair follicles, preventing DHT from causing hair loss. However, there are some key differences between Fluridil and these other topical antiandrogens.
One of the main distinctions is the stability and degradation of Fluridil. Unlike RU58841 and pyrilutamide, Fluridil rapidly degrades into inactive metabolites making it likely to cause systemic side effects, as it doesn’t accumulate in the body. Additionally, Fluridil has undergone more extensive clinical testing, with published studies demonstrating its safety and efficacy.
In conclusion, individuals might choose Fluridil over other hair loss treatments like finasteride, dutasteride, RU58841, and pyrilutamide due to its targeted action, minimal systemic side effects, and favorable safety profile. While each person’s choice will depend on their specific concerns and preferences, Fluridil offers a promising alternative for those seeking a gentler and more localized approach to hair loss treatment.
The price of fluridil vs. other hair loss treatments.
Eucapil is priced between $50 to $100 for a month’s supply of 30 ampoules, a cost which may be attributed to its lack of FDA approval, which impacts its pricing in two ways. Firstly, it is not readily available in the market. Secondly, it is not as commonly prescribed or used as other hair loss treatments like minoxidil and finasteride, which can limit the economies of scale that would result in lower production costs. Additionally, because of its rapid degradation once exposed to moisture, Eucapil is packaged in individual glass ampoules which may contribute to production costs.
Fluridil for hair loss – Frequently Asked Questions
Is Fluridil for hair loss available over the counter?
Fluridil is available by prescription only. Consult a healthcare professional for more information and to determine if fluridil is the right treatment for you.
Can fluridil be used by both men and women?
Yes, fluridil can be used by both men and women experiencing hair loss due to AGA
Can Fluridil be used at the same time as other hair loss treatments?
In some cases, Fluridil may be used alongside other hair loss treatments but it’s essential to consult a healthcare professional before combining treatments to minimise the risk of side effects and treatment interactions.
Are there any known drug interactions with Fluridil?
Fluridil has no well-documented medication interactions. However, before beginning Fluridil, always advise your healthcare professional of any drugs or supplements you’re taking.
When is the best time to apply fluridil?
Ideally fluridil should be used at nighttime and left on the scalp for as long as possible, however, it can be used any time of day, as long as the scalp is dry.
Research can be compared to the published data for these and other products.
Hair loss can be a distressing experience, but Fluridil or Eucapil offer a potential solution for men and women struggling with AGA. By understanding its mechanism, benefits, potential side effects, and stability, you can make an informed decision about whether this treatment is right for you.
While Eucapil is authorized as a cosmetic hair care agent for topical use in the Czech and Slovak Republics and is hence available in other EU countries, it lacks FDA approval and is, therefore, challenging to acquire in the US. For this reason, it is a more expensive and less commonly used treatment than the proven first-line treatments for AGA, such as minoxidil and finasteride. Before starting Fluridil or Eucapil, these treatments should be considered.
Remember to consult a healthcare professional before starting Fluridil and follow their recommendations to achieve the best possible results. With consistent use and patience, you may be well on your way to thicker, healthier hair.
- Rossi A, Anzalone A, Fortuna MC, Caro G, Garelli V, Pranteda G, et al. Multi-therapies in androgenetic alopecia: review and clinical experiences. Dermatologic Therapy. 2016;29(6):424-32.
- Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M. Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience. Dermatol Surg. 2002;28(8):678-85.
- Kucerova R, Bienova M, Novotný R, Fiurášková M, Hajduch M, Sovak M. Current therapies of female androgenetic alopecia and use of fluridil, a novel topical antiandrogen. Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae. 2006;79:35-48.
- Connors KA, Amidon GL, Stella VJ. Chemical stability of pharmaceuticals : a handbook for pharmacists. 2nd ed ed. New York: Wiley; 1986.